Related Experiment Video

Updated: Apr 11, 2026

Operant Procedures for Assessing Behavioral Flexibility in Rats
08:30

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

21.8K

Neural substrates of cognitive flexibility in cocaine and gambling addictions

Antonio Verdejo-Garcia1, Luke Clark2, Juan Verdejo-Román2

  • 1Antonio Verdejo-Garcia, PhD, School of Psychology and Psychiatry, Monash University, Melbourne, Australia, Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain and Red de Trastornos Adictivos, Universidad de Granada. Granada, Spain; Luke Clark, PhD, Department of Psychology, Centre for Gambling Research at UBC, University of British Columbia, Canada; Juan Verdejo-Román, MSc, Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain; Natalia Albein-Urios, PhD, Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain; José M. Martinez-Gonzalez, PhD, Red de Trastornos Adictivos, Universidad de Granada, Granada, Spain and Centro Provincial de Drogodependencias, Diputacion de Granada, Granada, Spain; Blanca Gutierrez, PhD, Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain, Department of Psychiatry, Universidad de Granada, Granada, Spain and CIBERSAM, Carlos III Health Institute, Barcelona, Spain; Carles Soriano-Mas, PhD, Department of Psychiatry, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain and CIBERSAM, Carlos III Health Institute, Barcelona, Spain, Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain Antonio.Verdejo@monash.edu.

The British Journal of Psychiatry : the Journal of Mental Science
|June 6, 2015
PubMed
Abstract

More Related Videos

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

11.3K
A Conflict Model of Reward-seeking Behavior in Male Rats06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

8.0K

Related Concept Videos

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
1.4K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.6K
Instinctive Drift01:05

Instinctive Drift

Instinctive drift refers to the tendency of animals to revert to their innate behaviors despite repeated reinforcement. Breland and Breland demonstrated this concept in an experiment with a raccoon. The raccoon was trained to pick up two coins and place them in a container in exchange for food. Initially, the raccoon learned to associate the coins with food, making them a conditioned stimulus or a substitute for food. However, over time, the raccoon became less willing to put the coins into the...
1.3K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
4.0K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
895
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
2.0K