Related Experiment Video
Updated: Apr 11, 2026
11:27
Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
Published on: November 18, 2013
12.8K
Summary
Adult T-cell leukemia is organized hierarchically. A small group of transformed T memory stem cells sustains this cancer, according to new research.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Adult T-cell leukemia (ATL) is a heterogeneous malignancy.
- Understanding the cellular hierarchy is crucial for effective treatment.
Purpose of the Study:
- To investigate the cellular organization and sustaining mechanisms of adult T-cell leukemia.
- To identify the specific cell population responsible for ATL maintenance.
Main Methods:
- The study by Nagai et al. analyzed the cellular components of adult T-cell leukemia.
- Investigated the hierarchical structure and stem cell populations within the leukemia.
Main Results:
- Evidence suggests adult T-cell leukemia exhibits a hierarchical organization.
- A distinct, small population of transformed T memory stem cells was identified as the key driver.
Conclusions:
- Adult T-cell leukemia is sustained by a small subset of T memory stem cells.
- Targeting these specific stem cells may offer a novel therapeutic strategy for ATL.
Related Concept Videos
01:17Stem Cell Culture
6.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.6K
00:58Embryonic Stem Cells
33.5K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
33.5K
00:57Embryonic Stem Cells
6.0K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
6.0K
01:33Adult Stem Cells
34.5K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
34.5K
01:19Multipotency of Hematopoietic Stem Cells
4.2K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.2K
01:19Mesenchymal Stem Cells
6.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.1K