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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Structure and Function of Platelets01:18

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Related Experiment Video

Updated: Apr 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

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A paradigm shift in platelet transfusion therapy.

Jaehyung Cho1

  • 1UNIVERSITY OF ILLINOIS COLLEGE OF MEDICINE.

Blood
|June 6, 2015
PubMed
Summary

Researchers found that lab-grown human megakaryocytes, when infused into mice, successfully produced functional platelets. This breakthrough offers a potential alternative to traditional platelet transfusion therapy for patients needing platelet support.

Area of Science:

  • Hematology
  • Cell Biology
  • Transfusion Medicine

Background:

  • Platelet transfusion therapy is crucial for managing bleeding disorders.
  • Scalable generation of ex vivo-derived functional platelets remains a significant challenge.
  • Megakaryocytes are the cells responsible for platelet production.

Purpose of the Study:

  • To investigate the therapeutic potential of ex vivo-derived human megakaryocytes for platelet production.
  • To determine the fate and function of infused megakaryocytes in vivo.
  • To explore a novel strategy for platelet transfusion alternatives.

Main Methods:

  • Ex vivo generation of human megakaryocytes.
  • Infusion of these cells into a mouse model.
  • Analysis of megakaryocyte localization within the pulmonary vasculature.

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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

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  • Assessment of functional platelet release into circulation.

    • Main Results:

    • Ex vivo-derived human megakaryocytes were successfully trapped in the pulmonary vasculature of mice.
    • These trapped megakaryocytes released functional platelets into the bloodstream.
    • The generated platelets demonstrated potential for therapeutic use.

    Conclusions:

    • Infused ex vivo-derived human megakaryocytes can serve as a source of functional platelets.
    • Pulmonary vasculature trapping is a key mechanism for megakaryocyte-mediated platelet production in this model.
    • This approach presents a promising alternative to conventional platelet transfusion therapy.