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Updated: Apr 11, 2026
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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
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CD4+CD29+T cells are blamed for the persistent inflammatory response in ulcerative colitis
Yuzhen Zhu1, Yanling Feng2, Hongbo Liu3
1Guangdong Key Laboratory for Research and Development of Natural Drug, Research Institute of Traditional Chinese Medicine, Guangdong Medical College Zhanjiang City, Guangdong, China.
Summary
CD4+CD29+T cells and MPO/VCAM-1 are upregulated in ulcerative colitis (UC) patients and a rat model. These markers correlate with disease severity, suggesting their role in UC inflammation.
Area of Science:
- Immunology
- Gastroenterology
- Oncology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease linked to colorectal cancer.
- Accurate diagnosis and understanding of UC pathogenesis are crucial.
Purpose of the Study:
- To investigate the expression trends of CD4+CD29+T cells, MPO, and VCAM-1 in a rat UC model and human UC patients.
- To evaluate the correlation between CD4+CD29+T cells and UC disease severity.
Main Methods:
- A rat model of UC was induced using DNCB liquid and acetate solution.
- Expression levels of CD4+CD29+T cells, MPO, and VCAM-1 were measured in rat and human samples.
- Pearson correlation analysis was used to assess the relationship with disease severity scores (DAI).
Main Results:
- Upregulated expression of CD4+CD29+T cells, MPO, and VCAM-1 was observed in both rat UC models and human UC patients.
- Expression levels were highest in rats at two weeks post-induction and in active UC patients.
- CD4+CD29+T cells in peripheral blood positively correlated with disease activity scores in both rats and humans.
Conclusions:
- CD4+CD29+T cells are identified as key effector cells in the persistent inflammation of UC.
- VCAM-1 and CD29 may play a role in inducing the infiltration of these cells into the inflamed colon.
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