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Published on: October 12, 2017
Correlation between biochemical indicators of blood lipid with cerebral vascular diseases
Dongmei Wang1, Jun Hu1, Qiao Ma1
1Department of Laboratory Medicine, 161 Hospital of PLA Wuhan 430010, Hubei, China.
Insights
Elevated lipoprotein (a) (Lpa) levels are linked to increased risk of cerebral infarction, but not cerebral hemorrhage. Lpa may serve as a key biomarker for predicting stroke risk.
Area of Science:
- Neurology
- Biochemistry
- Cardiovascular Research
Background:
- Cerebrovascular diseases, including cerebral infarction and hemorrhage, pose significant health challenges.
- Biomarkers for predicting stroke risk are crucial for early intervention and management.
Purpose of the Study:
- To investigate the correlation between serum levels of cholesterol (chol), lipoprotein (a) (Lpa), and homocysteine (HCY) and the incidence of cerebral infarction and cerebral hemorrhage.
Main Methods:
- Analysis of data from 418 patients (318 with cerebral infarction, 100 with cerebral hemorrhage).
- Serum chol and HCY levels measured using GPO-PAP.
- Serum Lpa levels determined by latex agglutination turbidimetry.
Main Results:
- Significantly higher serum Lpa levels and anomaly ratio observed in cerebral infarction patients compared to cerebral hemorrhage patients (P<0.05).
- No significant changes in serum cholesterol or homocysteine levels were identified between the groups (P>0.05).
- Increased Lpa concentration was noted in cerebral infarction patients over 60 years of age (P<0.05).
Conclusions:
- Serum Lpa concentration is significantly correlated with the incidence of cerebral infarction.
- Lipoprotein (a) may function as an independent risk factor for cerebral infarction.
- Lpa shows potential as a valuable biomarker for identifying individuals at risk of cerebral infarction.
Objective:
The objective of this study was to investigate correlation of the changes in serum levels of cholesterol (chol), lipoprotein (a) (Lpa) and homocysteine (HCY) with incident cerebral infarction and cerebral hemorrhage.
Methods:
Data on a total of 418 patients (318 cerebral infarction events and 100 cerebral hemorrhage cases) were analyzed in this study. Serum chol and HCY levels were tested by means of GPO-PAP. Serum Lpa levels were measured using latex agglutination turbidimetry.
Results:
Patients with cerebral infarction showed significantly higher serum Lpa levels and anomaly ratio than those with cerebral hemorrhage (P<0.05), while no significant changes were identified for chol and HCY (P>0.05). Analyses by age indicated substantially increased Lpa concentration among cerebral infarction patients>60 years of age (P<0.05). No statistical significance was observed in other analyses carried out in the study.
Conclusion:
These results demonstrate that Lpa concentration is clearly correlated with cerebral infarction incidence. Lpa may act as an independent risk factor and could be used as a biomarker for this disease.
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