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Association between ERCC5 gene polymorphisms and breast cancer risk
Nari Na1, Eer Dun2, Lidong Ren3
1Department of General Surgery, Nanfang Hospital, Southern Medical University Guangzhou, China ; Department of Thyroid, Breast, Hernia and Vascular Surgery, Inner Mongolia People's Hospital Hohhot, China.
The ERCC5 rs2094258 polymorphism is linked to a higher risk of breast cancer, especially in tobacco smokers. This genetic variation may play a role in breast cancer development.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Breast cancer is a significant global health concern.
- Genetic factors, including DNA repair gene polymorphisms, are implicated in breast cancer etiology.
- The Excision Repair Cross-Complementation group 5 (ERCC5) gene is involved in DNA repair pathways.
Purpose of the Study:
- To investigate the association between specific ERCC5 gene polymorphisms and breast cancer risk.
- To evaluate the potential modifying effect of tobacco smoking on this association.
Main Methods:
- A case-control study was conducted with 325 breast cancer patients and 325 controls.
- Genotyping of ERCC5 polymorphisms (rs1047768, rs2094258, rs2296147, rs751402, rs873601) was performed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
- Logistic regression analysis was employed to assess the risk associated with different genotypes.
Main Results:
- The AA genotype of ERCC5 rs2094258 was associated with an increased risk of breast cancer (OR = 1.80, 95% CI: 1.12-2.92).
- Individuals with the GA+GG genotypes of rs2094258 showed a significantly higher risk of breast cancer among tobacco smokers (OR = 7.35, 95% CI: 1.21-47.20).
Conclusions:
- The ERCC5 rs2094258 polymorphism may be a contributing factor to breast cancer risk.
- Tobacco smoking may interact with ERCC5 rs2094258 to further elevate breast cancer risk.
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