Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.4K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.4K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

2.3K
2.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.4K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma.

Annals of clinical and translational neurology·2026
Same author

Application of a machine learning-based PANoptosis-immune-related gene risk score model in prognostic stratification and immunotherapy benefit prediction for glioblastoma.

Computer methods in biomechanics and biomedical engineering·2026
Same author

Trigeminal somatosensory evoked potentials for intraoperative monitoring and prognostic prediction in microvascular decompression for trigeminal neuralgia: a prospective cohort study.

Frontiers in neurology·2026
Same author

CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold.

Nature cell biology·2025
Same author

Crystal structures of agonist-bound human cannabinoid receptor CB<sub>1</sub>.

Nature·2025
Same author

Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB<sub>1</sub>.

Nature·2025

Related Experiment Video

Updated: Apr 11, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.3K

Chemotherapy targeting cancer stem cells.

Haiguang Liu1, Lin Lv2, Kai Yang2

  • 1Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University Fuxue Road No. 2, Wenzhou, 325000, China ; Department of Pathology, Southern Hospital of Southern Medical University Guangzhou Road No. 1838, Guangzhou, 510515, China.

American Journal of Cancer Research
|June 6, 2015
PubMed
Summary
This summary is machine-generated.

This review explores novel chemotherapy strategies targeting cancer stem cells (CSCs) to overcome resistance and improve treatment efficacy. Understanding CSCs offers new avenues for more effective cancer therapies.

Keywords:
Side effectsbiomarkerscancer hierarchydrug delivery systemmultifunctional carrier

More Related Videos

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

5.3K
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

12.3K

Related Experiment Videos

Last Updated: Apr 11, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.3K
Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

5.3K
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

12.3K

Area of Science:

  • Oncology
  • Cancer Biology
  • Drug Discovery

Background:

  • Conventional chemotherapy offers survival benefits but has limitations.
  • Inefficiency and resistance are linked to cancer stem cells (CSCs).
  • CSCs are implicated in cancer relapse and metastasis.

Purpose of the Study:

  • To review novel strategies for targeting cancer stem cells (CSCs).
  • To explore new drugs and delivery systems for CSC-targeted chemotherapy.
  • To discuss combination therapies for comprehensive cancer treatment.

Main Methods:

  • Literature review of CSC enrichment methods.
  • Analysis of novel drug discovery for CSCs.
  • Examination of drug delivery systems targeting CSCs.
  • Discussion of CSC hierarchy and combination therapy.

Main Results:

  • Identified CSC enrichment techniques.
  • Highlighted emerging drugs and delivery systems for CSCs.
  • Discussed the complexity of CSC hierarchy.
  • Proposed combination therapies for CSCs and non-stem cancer cells.

Conclusions:

  • Targeting cancer stem cells (CSCs) is crucial for improving chemotherapy.
  • Novel CSC-targeting strategies hold promise for future cancer treatment.
  • Further research into CSCs can lead to more effective and less toxic therapies.