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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
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Pancreatic cancer stem cells.

Ya-Yun Zhu1, Zhou Yuan1

  • 1Department of Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital Shanghai, 200233, China.

American Journal of Cancer Research
|June 6, 2015
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive tumor initiation and growth. This review explores pancreatic CSCs signaling pathways and challenges in developing targeted CSC therapies.

Keywords:
CSC-targeted therapeuticPancreatic cancercancer stem cellsmicroRNAsignaling pathway

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Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Emerging evidence supports the cancer stem cells (CSCs) theory.
  • CSCs are a small subpopulation responsible for cancer initiation and malignant behavior.
  • CSCs possess self-renewal and differentiation capabilities, forming tumors hierarchically.

Purpose of the Study:

  • To articulate signaling pathways regulating pancreatic CSC characteristics.
  • To provide insights into CSC-targeted therapeutics for pancreatic cancer.
  • To highlight challenges in developing effective CSC-based therapies.

Main Methods:

  • Review of current literature on cancer stem cells.
  • Analysis of signaling pathways involved in pancreatic CSC maintenance.
  • Examination of targeted therapeutic strategies against CSCs.

Main Results:

  • Identification of key signaling pathways governing pancreatic CSC properties.
  • Discussion of the complexities and limitations of current CSC-targeted treatments.
  • Highlighting significant challenges in translating CSC research into clinical practice.

Conclusions:

  • Understanding CSC signaling is crucial for pancreatic cancer treatment.
  • Targeted therapies for pancreatic CSCs face substantial obstacles.
  • Further research is needed to overcome challenges in CSC-based cancer therapeutics.