Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Virus01:28

Introduction to Virus

1.2K
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
1.2K
Adherens Junctions01:24

Adherens Junctions

6.2K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
6.2K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

9.1K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
9.1K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.2K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.2K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.3K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.3K
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

3.4K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimized AAV capsids robustly transduce airway epithelial cells.

bioRxiv : the preprint server for biology·2026
Same author

Lassa and Mopeia viruses produce different RIG-I-activating RNA in the absence of a functional viral exoribonuclease domain.

Journal of virology·2026
Same author

Lentiviral-mediated gene complementation to rescue pathogenic ABCA3 variants.

American journal of respiratory cell and molecular biology·2026
Same author

Considerations for early life genetic therapies in cystic fibrosis.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

Subacute Sclerosing Panencephalitis: How Measles Virus Adapts to the Brain.

Annual review of virology·2026
Same author

Three paradoxical paradigms of measles virus.

PLoS pathogens·2026

Related Experiment Video

Updated: Jan 17, 2026

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment
08:34

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

10.0K

Connections matter--how viruses use cell–cell adhesion components.

Mathieu Mateo, Alex Generous, Patrick L Sinn

    Journal of Cell Science
    |June 6, 2015
    PubMed
    Summary

    Viruses exploit epithelial cell-cell adhesion structures to spread, using them as receptors to navigate or disrupt the epithelial barrier. Some viruses utilize these pathways for efficient transmission and even cancer therapy.

    More Related Videos

    Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
    11:45

    Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers

    Published on: March 8, 2012

    12.7K
    In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells
    05:57

    In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells

    Published on: May 16, 2011

    26.5K

    Related Experiment Videos

    Last Updated: Jan 17, 2026

    Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment
    08:34

    Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

    Published on: March 2, 2016

    10.0K
    Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
    11:45

    Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers

    Published on: March 8, 2012

    12.7K
    In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells
    05:57

    In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells

    Published on: May 16, 2011

    26.5K

    Area of Science:

    • Cell Biology
    • Virology
    • Immunology

    Background:

    • Epithelial cells form a crucial barrier against pathogen invasion.
    • Viruses face multiple obstacles when attempting to penetrate epithelial tissues.
    • Epithelial junctions, such as tight and adherens junctions, normally prevent viral transit.

    Purpose of the Study:

    • To discuss how viruses utilize the apical junction complex for epithelial spread.
    • To highlight viral strategies for overcoming epithelial barriers.
    • To explore the role of cell adhesion molecules in viral pathogenesis and oncolytic virotherapy.

    Main Methods:

    • Review of scientific literature on viral interactions with epithelial cells.
    • Analysis of viral mechanisms for exploiting cell-cell adhesion structures.
    • Discussion of viral receptor usage for epithelial penetration and therapeutic applications.

    Main Results:

    • Viruses have evolved diverse strategies to breach or navigate epithelial barriers.
    • Components of the apical junction complex serve as viral receptors.
    • Some viruses disrupt epithelial integrity, while others spread laterally by preserving it.
    • Enveloped viruses use nectins as receptors for hidden transmission.
    • Oncolytic viruses utilize cell adhesion molecules for tumor penetration.

    Conclusions:

    • Viruses adeptly exploit epithelial cell-cell adhesion complexes for transmission and replication.
    • Understanding these viral strategies is key to developing antiviral therapies and oncolytic treatments.
    • Cell adhesion molecules are critical determinants of viral tropism and pathogenesis.