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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
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Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Basophil Activation Test for Allergy Diagnosis
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South African food allergy consensus document 2014.

M E Levin, C L Gray, E Goddard

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |June 6, 2015
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    Summary
    This summary is machine-generated.

    South Africa now has local food allergy guidelines to manage increasing global prevalence. These guidelines detail diagnosis, treatment, and risk reduction strategies for food allergies and anaphylaxis.

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    Area of Science:

    • Allergy and Immunology
    • Gastroenterology
    • Clinical Nutrition

    Background:

    • Rising global prevalence of food allergy and anaphylaxis necessitates local guidelines.
    • Existing South African guidelines for food allergy were absent.
    • Food allergies present complex challenges due to multiple allergen reactions and varied responses.

    Purpose of the Study:

    • To establish the first local South African food allergy guidelines.
    • To provide comprehensive recommendations for diagnosis and management.
    • To address the increasing burden of food allergy and anaphylaxis.

    Main Methods:

    • Development of guidelines by leading South African societies (ALLSA, SAGES, ADSA).
    • Emphasis on detailed patient history for identifying reaction types and severity.
    • Integration of diagnostic tools including skin-prick tests, specific immunoglobulin E (IgE) tests, oral food challenges, and elimination diets.

    Main Results:

    • Guidelines recommend strict avoidance of causative foods with nutritional support.
    • Acute management protocols include adrenaline administration and resuscitation.
    • Risk-reduction strategies involve patient education, emergency action plans, and medical alert devices.

    Conclusions:

    • The new guidelines provide a framework for managing food allergy in South Africa.
    • Accurate diagnosis relies on a combination of history, sensitization tests, and challenges.
    • Effective management requires strict avoidance, prompt emergency treatment, and comprehensive risk mitigation.