Related Experiment Video
Updated: Apr 11, 2026

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
Published on: October 26, 2017
Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency
Lorenz Studer1, Elsa Vera1, Daniela Cornacchia1
1Developmental Biology and Center of Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10003, USA.
Reprogramming adult cells to induced pluripotent stem cells (iPSCs) resets cellular age, posing challenges for disease modeling but offering new ways to study aging and rejuvenation.
Area of Science:
- Stem cell biology
- Cellular reprogramming
- Aging research
Background:
- Adult somatic cells can be reprogrammed to a pluripotent state, forming induced pluripotent stem cells (iPSCs).
- This reprogramming process resets cellular age, creating an embryonic-like state.
- The age reset in iPSCs presents challenges for modeling age-related diseases, especially late-onset conditions.
Purpose of the Study:
- To discuss the implications of cellular age reversal during reprogramming.
- To explore how iPSC technology can be utilized for studying aging processes.
- To highlight the potential for precise programming of cellular age alongside cell-fate specification.
Main Methods:
- Review of current iPSC reprogramming techniques.
- Discussion of challenges in modeling age-related diseases with iPSCs.
- Exploration of novel methods for mimicking age-related changes in iPSC derivatives.
Main Results:
- Cellular age reset in iPSCs is a significant hurdle for modeling late-onset diseases.
- The age reset phenomenon provides unique opportunities to study cellular rejuvenation in real-time.
- iPSC research can transform the study of aging and enable controlled manipulation of cellular age.
Conclusions:
- iPSC technology offers a powerful platform for investigating cellular aging and rejuvenation.
- Novel methodologies are needed to incorporate age-related changes into iPSC-based disease models.
- Future research can leverage iPSCs to precisely control cellular age and cell-fate specification for advanced studies.
More Related Videos
10:52Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
Published on: January 19, 2020
07:08Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
Published on: February 2, 2024
Related Concept Videos
Somatic to iPS Cell Reprogramming
Induced Pluripotent Stem Cells
Induced Pluripotent Stem Cells
Somatic...
Induced Pluripotent Stem Cells
Methods of Nuclear Reprogramming
Introduction to Nuclear Reprogramming