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Updated: Apr 11, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography
Jianhua Wang1, Ayman Aljohani1, Teresia Carreon1
1Bascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136.
Abstract:
The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values. We present two (spectroscopic and magnetomotive) optical coherence tomography (OCT) approaches for in vivo cochlin quantification in a periodic manner. The cochlin-antibody OCT signal remains stable for up to 24 hours as seen at 3.5 hours after injection allowing for repeated quantification in the living mouse eyes.

