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Nuclease hypersensitivity of the rat cytochrome P450IA1 gene
1Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68105.
Biochemical Pharmacology
|December 15, 1989
Abstract:
The bovine pancreatic deoxyribonuclease I (DNAase I) hypersensitivity of the rat cytochrome P450IA1 gene was investigated. A nuclease-hypersensitive region was observed at approximately 3.2 to 5.1 kilobase pairs upstream of exon 1 in adult and fetal rat liver. This region did not necessarily correlate with gene expression following 3-methylcholanthrene induction, although it may determine the potential for inducibility of this gene.