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Updated: Apr 11, 2026
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Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
Published on: August 11, 2018
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Antimicrobial peptides: Possible anti-infective agents.
Jayaram Lakshmaiah Narayana1, Jyh-Yih Chen2
1Doctoral Degree Program in Marine Biotechnology, Institute of Cellular and Orgasmic Biology, Academia Sinica and National Sun-Yat Sen University, Kaohsiung, Taiwan; Marine Research Station, Institute of Cellular and Orgasmic Biology, Academia Sinica, Jiaushi, Ilan, Taiwan.
Peptides
|June 7, 2015
Summary
Antimicrobial peptides (AMPs) offer a promising alternative to traditional antibiotics against drug-resistant infections. This review covers AMPs in development, their production, and delivery systems for effective therapeutic use.
Area of Science:
- Microbiology
- Biotechnology
- Pharmacology
Background:
- Rising threat of multidrug-resistant infections globally.
- Decreased pharmaceutical investment in antibiotic research and development.
- Emergence of novel therapeutic strategies from small companies and academia.
Purpose of the Study:
- To review antimicrobial peptides (AMPs) as a promising alternative to conventional antimicrobial drugs.
- To discuss AMPs currently in various stages of clinical development.
- To examine production methods and delivery systems for AMPs.
Main Methods:
- Review of scientific literature on antimicrobial peptides.
- Analysis of anion and cationic AMPs in preclinical and clinical development.
- Assessment of current production and delivery technologies for AMPs.
Main Results:
- Antimicrobial peptides (AMPs) demonstrate broad-spectrum activity against bacteria, fungi, viruses, and parasites.
- AMPs possess immunomodulatory properties and respond to immune stimuli.
- Several AMPs are progressing through clinical trials, with some available for topical applications.
Conclusions:
- Antimicrobial peptides (AMPs) represent a vital frontier in combating drug-resistant infections.
- Further improvements in AMP production and delivery are crucial for widespread clinical application.
- Continued research and development of AMPs are essential to address global health challenges.
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