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The DNA Helix

The DNA Helix

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.

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DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...

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Related Experiment Video

Updated: Apr 11, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

Helix mimetics: Recent developments.

Andrew J Wilson¹

¹School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK; Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.

Progress in Biophysics and Molecular Biology

|June 7, 2015

Summary

This summary is machine-generated.

Developing small molecule helix mimetics offers a promising strategy for inhibiting protein-protein interactions (PPIs). This review highlights recent advances in proteomimetics for targeting alpha-helix mediated PPIs.

Keywords:

Chemical biology Inhibitors Protein–protein interactions α-Helix α-Helix mimetic

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Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Published on: November 12, 2014

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Last Updated: Apr 11, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

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Published on: August 1, 2018

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Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

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Area of Science:

Chemical Biology
Drug Discovery
Computational Chemistry

Background:

Protein-protein interactions (PPIs) are challenging drug targets due to large, ill-defined interfaces.
Alpha-helix mediated PPIs offer a more defined interface, suitable for targeted inhibition.
Constrained peptides have shown success, but small molecule alternatives are desirable.

Purpose of the Study:

To review recent developments in small molecule alpha-helix mimetics (proteomimetics).
To provide a critical overview of successes, limitations, and future directions in helix mimetic research.

Main Methods:

Literature review of recent advancements in proteomimetic design and application.
Analysis of case studies demonstrating the efficacy of small molecule helix mimetics.
Critical evaluation of the potential and limitations of current proteomimetic strategies.

Main Results:

Small molecule helix mimetics can effectively mimic the presentation of key amino acid side chains.
Proteomimetics offer a viable alternative to constrained peptides for targeting alpha-helix mediated PPIs.
Significant progress has been made, though the approach requires further elaboration.

Conclusions:

Small molecule helix mimetics represent a developing field with significant therapeutic potential.
Further research is needed to overcome limitations and fully realize the promise of proteomimetics.
This approach holds promise for future drug discovery efforts targeting PPIs.