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Updated: Apr 11, 2026

Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
Published on: October 26, 2017
An efficient synthesis and in vitro antibacterial evaluation of ruthenium-quinolinol complexes
Mahima Malipeddi1, Chirag Lakhani1, Mohit Chhabra1
1Pharmaceutical Chemistry Division, School of Advance Sciences, VIT University, Vellore 632014, Tamilnadu, India.
Abstract:
A series of ruthenium-quinolinol complexes were synthesized using a simple and effective pathway and their in vitro antibacterial activity against various resistant gram-positive and gram-negative bacteria were evaluated. It was established that compound [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) & [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3e) were significantly active against Staphylococcus aureus, Escherichia coli, Bacillus subtilis &Salmonella sp. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of complex [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) was measured by UV spectroscopy & time dependent NMR spectroscopy. Compound 3b also shows remarkable fluorescence.
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