Nouvelle cuisine: platelets served with inflammation
Rick Kapur1, Anne Zufferey2, Eric Boilard3
1Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada; Canadian Blood Services, Toronto, Ontario M5B 1W8, Canada;
Journal of Immunology (Baltimore, Md. : 1950)
|June 7, 2015
Summary
Platelets, crucial for blood clotting, also play a significant role in infection and inflammation. This review explores their immune functions beyond hemostasis.
Area of Science:
- Immunology
- Hematology
- Cell Biology
Background:
- Platelets are primarily known for hemostasis.
- Emerging evidence highlights platelet involvement in infection and inflammation.
Purpose of the Study:
- To review the non-hemostatic functions of platelets in inflammatory settings.
- To emphasize the immune roles of platelets.
Main Methods:
- Literature review of current research on platelet immunology.
- Analysis of platelet characteristics relevant to immune responses.
Main Results:
- Platelets bind pathogens and secrete immunomodulatory molecules.
- Platelet receptors like TLRs detect pathogen-associated molecular patterns.
- Platelets contain translatable RNA and release microparticles with inflammatory cargo.
Conclusions:
- Platelets possess significant non-hemostatic immune functions.
- Platelet activity is crucial in infection and inflammation.
- Thrombocytopenia can occur during acute infections due to platelet consumption.
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