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Related Experiment Video

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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

A transparent epidural electrode array for use in conjunction with optical imaging.

Nobuo Kunori¹, Ichiro Takashima²

¹Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan; Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba 305-8568, Japan; RIKEN Brain Science Institute, 2-1 Hirosawa, Wako 351-0198, Japan.

Journal of Neuroscience Methods

|June 7, 2015

Summary

This summary is machine-generated.

Researchers developed a transparent electrode array for simultaneous optical imaging and cortical stimulation. This innovation overcomes the field-of-view obstruction caused by traditional electrodes, enabling high-resolution functional brain mapping.

Keywords:

Optical imaging Recording and stimulation Transparent electrode Voltage-sensitive dye

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Area of Science:

Neuroscience
Biomedical Engineering
Optical Imaging

Background:

Direct cortical stimulation combined with optical imaging offers high-resolution functional mapping.
Conventional stimulating electrodes obstruct the field of view, limiting image acquisition in underlying cortical areas.

Purpose of the Study:

To develop a transparent electrode array for simultaneous optical imaging and direct cortical stimulation.
To overcome the limitations of existing electrode designs that impede optical monitoring.

Main Methods:

Fabrication of a 16-contact transparent electrode array using photolithography on an indium tin oxide (ITO)-coated polyethylene terephthalate (PET) sheet.
Development of a transparent metal circuit pattern within the ITO layer for complete transparency.

Main Results:

Successful cortical stimulation and monitoring of evoked neural activity using optical imaging with a voltage-sensitive dye through the transparent array.
Detection of optical signals directly beneath the stimulating electrodes.
Demonstrated utility for epidural recording of somatosensory evoked potentials.

Conclusions:

The developed transparent epidural electrode facilitates both stimulation and recording.
It enables optical signal detection from the underlying cortex without interference, enhancing functional brain mapping capabilities.