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Published on: February 15, 2016
The structure of acetylarsenocholine bromide
A Kostick1, A S Secco, M Billinghurst
1Department of Chemistry, University of Manitoba, Winnipeg, Canada.
Acta Crystallographica. Section C, Crystal Structure Communications
|September 15, 1989
Summary
This study reveals acetylarsenocholine bromide’s crystal structure, showing a trans-gauche conformation similar to acetylcholine. Bromide ions link the arsonium groups, providing insights into organoarsenic compounds.
Area of Science:
- Inorganic Chemistry
- Crystallography
- Structural Chemistry
Background:
- Acetylcholine is a crucial neurotransmitter with a well-studied structure.
- Organoarsenic compounds exhibit diverse chemical properties and biological activities.
- Understanding the structural nuances of acetylcholine analogs is vital for pharmacological research.
Purpose of the Study:
- To determine the crystal structure of acetylarsenocholine bromide.
- To elucidate the conformational properties of acetylarsenocholine in the solid state.
- To compare the structure of acetylarsenocholine bromide with acetylcholine salts.
Main Methods:
- Single-crystal X-ray diffraction analysis was performed.
- The crystal structure was solved and refined.
- Crystallographic data (space group, unit cell dimensions, R-factor) were obtained.
Main Results:
- Acetylarsenocholine bromide crystallizes in the orthorhombic system (P2(1)2(1)2(1)).
- The compound adopts a trans-gauche conformation in its crystalline state.
- Each bromide ion bridges four arsonium groups, indicating a specific intermolecular interaction.
Conclusions:
- The determined conformation is analogous to the solution conformation of acetylcholine.
- The crystal packing reveals a unique interaction pattern involving bromide ions and arsonium centers.
- This structural data contributes to the understanding of arsenic-containing analogs of biologically significant molecules.
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