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Updated: Apr 11, 2026

High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water
Published on: April 28, 2022
Some thermodynamical aspects of protein hydration water
Francesco Mallamace1, Carmelo Corsaro1, Domenico Mallamace2
1Dipartimento di Fisica e Scienze della Terra, Università di Messina and CNISM, I-98168 Messina, Italy.
Abstract:
We study by means of nuclear magnetic resonance the self-diffusion of protein hydration water at different hydration levels across a large temperature range that includes the deeply supercooled regime. Starting with a single hydration shell (h = 0.3), we consider different hydrations up to h = 0.65. Our experimental evidence indicates that two phenomena play a significant role in the dynamics of protein hydration water: (i) the measured fragile-to-strong dynamic crossover temperature is unaffected by the hydration level and (ii) the first hydration shell remains liquid at all hydrations, even at the lowest temperature.
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