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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Does prediabetes cause small fiber sensory polyneuropathy? Does it matter?
C D Kassardjian1, P J B Dyck1, J L Davies1
1Peripheral Neuropathy Research Laboratory, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Journal of the Neurological Sciences
|June 8, 2015
Summary
Prediabetes does not increase the risk of small fiber sensory distal polyneuropathy (DPN). Only newly diagnosed diabetes showed increased foot hypoalgesia, suggesting lifestyle changes for prediabetes patients.
Area of Science:
- Neurology
- Endocrinology
- Diabetology
Background:
- The link between prediabetes and distal polyneuropathy (DPN) is debated.
- Small fiber sensory DPN is a potential complication of metabolic dysfunction.
Purpose of the Study:
- To investigate if prediabetes is associated with an increased prevalence of small fiber sensory DPN.
- To compare neuropathic symptoms and quantitative sensory testing (QST) abnormalities between prediabetes and healthy individuals.
Main Methods:
- Prospective cohort study including healthy subjects and individuals with prediabetes.
- Assessment of neuropathic sensory symptoms, pain, hyperalgesia, and hypoalgesia using "smart" quantitative sensation testing (QST).
- Comparison of symptom prevalence and QST abnormalities between groups.
Main Results:
- No significant increase in positive neuropathic sensory or pain symptoms was observed in the prediabetes group.
- Quantitative sensory testing did not reveal increased hyperalgesia or hypoalgesia in individuals with prediabetes.
- An increased prevalence of foot hypoalgesia was found exclusively in the group with newly diagnosed diabetes.
Conclusions:
- Small fiber sensory DPN was not found to be more prevalent in prediabetes based on symptoms and QST.
- Physicians should promote healthy living and weight loss in prediabetes due to links with vascular complications.
- Alternative causes for distal neuropathy should be ruled out before attributing it to prediabetes.
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