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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment
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Imaging the Tumor Microenvironment.

Valerie S LeBleu1

  • 1From the Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX.

Cancer Journal (Sudbury, Mass.)
|June 8, 2015
PubMed
Summary

The tumor microenvironment (TME) significantly impacts solid tumors. This article reviews current and emerging cancer imaging techniques for TME characterization, crucial for accurate diagnosis and treatment.

Area of Science:

  • Oncology
  • Medical Imaging
  • Cancer Biology

Background:

  • The tumor microenvironment (TME) is a complex and heterogeneous component of solid tumors.
  • Understanding the TME's dynamic functions is vital for cancer diagnosis and treatment.
  • Current imaging strategies focus on specific TME characteristics.

Purpose of the Study:

  • To summarize existing and novel cancer imaging modalities for TME assessment.
  • To highlight the importance of TME understanding in clinical oncology.
  • To discuss the implications of new TME insights for imaging data interpretation.

Main Methods:

  • Review of current cancer imaging modalities.
  • Exploration of novel imaging approaches for TME analysis.
  • Synthesis of recent research on TME functions in cancer progression.

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Main Results:

  • Active development of imaging strategies targeting TME characteristics.
  • Summary of currently used and emerging imaging techniques.
  • Emphasis on the critical role of TME in cancer progression.

Conclusions:

  • Accurate interpretation of imaging data requires understanding the TME.
  • Novel insights into TME roles necessitate the development of advanced imaging modalities.
  • The TME is a critical factor influencing cancer imaging and clinical care.