Related Experiment Video
Updated: Apr 11, 2026
A Rat Model of Middle Cerebral Artery Occlusion/Reperfusion Without Damaging the Anatomical Structure of Cerebral Vessels
Published on: May 17, 2024
[Relation between structure and function, of the cerebral artery "carotid" in laboratory rat submitted to atherogenic
L Ainouz1, A Baz2, M A Ammar Aouchiche2
1École nationale supérieur vétérinaire, BP 161 Hacène Badi, E L Harrach, Alger, Algérie; Laboratoire de biologie, physiologie animale et signalisation cellulaire, École normale supérieure Kouba, BP 92 Kouba, 1600 Alger, Algérie.
Objective Of The Study:
The aim of our investigation was the study of the pathophysiology of the carotid artery in cases of nutritional stress in male atheroresistant Wistar rats.
Materials And Methods:
Were administered daily by gavage to experimental rats a high fat diet consisting of peanut oil, cholesterol (3%) and sodium cholate (1%). Throughout this experiment, we conducted monitoring of some biochemical parameters and the morpho-histopathology of the carotid cerebral artery. The results obtained are compared to those of control rats in the same experimental conditions.
Results:
We found that this fat diet resulted in experimental rats disruption of biochemical tests and tissular and cellular alterations in carotid wall. Indeed, the biochemical examination shows a significant increase of the parameters studied. Morphological examination revealed thickening of the carotid wall and histopathological examination of this artery, highlights the installation of a vascular remodeling from thickening of the intima-media to the installation of a probable atherosclerosis accompanied by a possible hyalinization and a net fibrosis.
Conclusion:
At the end of this study, although notes that our fat diet could cause a metabolic disorder that can cause multiple tissue and cell damage observed in cerebral artery "carotid" of atheroresistant rats.
