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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
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Metabolomics and renal disease.
1Nephrology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Current Opinion in Nephrology and Hypertension
|June 8, 2015
Summary
Metabolomics offers new insights into kidney disease by analyzing metabolites in clinical and experimental settings. Challenges remain in standardizing results and understanding the kidney
Area of Science:
- Nephrology
- Metabolomics
- Biochemistry
Background:
- Metabolomics applications in nephrology have evolved from studying uremia to encompassing earlier stages of kidney disease.
- Studies have identified potential biomarkers for chronic kidney disease (CKD) incidence and progression.
- Significant challenges exist in synthesizing findings due to metabolite coverage inconsistencies across studies.
Purpose of the Study:
- To review recent metabolomics studies in renal disease.
- To outline current limitations in the existing literature.
- To highlight novel therapeutic opportunities identified through metabolomics.
Main Methods:
- Analysis of cross-sectional and longitudinal metabolomics data in kidney disease.
- Examination of renal metabolite handling and its impact on circulating metabolites.
- Integration of microbiome data to understand plasma metabolite origins.
Main Results:
- Metabolomics has identified signatures of altered mitochondrial function in diabetic nephropathy.
- Studies revealed a reliance on aerobic glucose metabolism in polycystic kidney disease.
- The microbiome is increasingly recognized as a source of functional plasma metabolites relevant to CKD.
Conclusions:
- High-throughput metabolomics provides valuable insights into renal disease across clinical, physiological, and experimental domains.
- Further standardization is needed to synthesize findings across diverse studies.
- Metabolomics is uncovering novel therapeutic targets for kidney diseases.
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