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Related Concept Videos

Clinical Trials01:16

Clinical Trials

11.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Data Reporting and Recording01:24

Data Reporting and Recording

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Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
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Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

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The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.5K
Preclinical Development: Overview01:28

Preclinical Development: Overview

6.5K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Data Resource Profile: Clinical Practice Research Datalink (CPRD).

Emily Herrett1, Arlene M Gallagher2, Krishnan Bhaskaran3

  • 1London School of Hygiene & Tropical Medicine, London, UK, Emily.Herrett@lshtm.ac.uk.

International Journal of Epidemiology
|June 8, 2015
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Summary
This summary is machine-generated.

The Clinical Practice Research Datalink (CPRD) provides anonymised UK primary care records for over 4.4 million patients. This rich dataset supports international epidemiological research across diverse health outcomes.

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Area of Science:

  • Health Informatics
  • Epidemiology
  • Public Health

Background:

  • The Clinical Practice Research Datalink (CPRD) is a large, anonymised primary care database in the UK.
  • It covers over 11.3 million patients from 674 general practices, with 4.4 million active patients meeting quality criteria.
  • CPRD data is broadly representative of the UK population in terms of demographics.

Purpose of the Study:

  • To highlight the utility of the CPRD as a rich data source for health research.
  • To inform researchers about the potential and complexities of using routinely collected electronic health records.
  • To showcase the extensive use of CPRD in epidemiological studies.

Main Methods:

  • Utilizes anonymised electronic health records from UK general practitioners.
  • Includes data on demographics, symptoms, diagnoses, therapies, and referrals.
  • Enhanced by linkage with secondary care, cohort, and mortality datasets for over half of patients.

Main Results:

  • CPRD has been instrumental in over 1000 research studies published in peer-reviewed journals.
  • The database facilitates research across a broad range of health outcomes.
  • Data linkage significantly enhances the scope of available research information.

Conclusions:

  • The CPRD is a valuable international resource for epidemiological research.
  • Researchers must navigate the complexities of electronic health records, including data completeness and disease definition.
  • The database offers comprehensive insights into patient health journeys within primary and secondary care settings.