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Developments in extracorporeal therapy for the poisoned patient
Nikunjkumar Patel1, George P Bayliss1
1Division of Kidney Diseases and Hypertension, Rhode Island and the Miriam Hospitals, Providence, RI, USA; Alpert Medical School, Brown University, Providence, RI, USA.
Advanced Drug Delivery Reviews
|June 9, 2015
Summary
Extracorporeal therapies are vital for poisoning and overdose treatment, but evidence is limited. New international guidelines and technologies aim to improve their optimal use and patient outcomes.
Area of Science:
- Nephrology
- Toxicology
- Pharmacology
Background:
- Extracorporeal therapies have evolved for poisoning, overdose, and kidney disease treatment.
- Advancements in drug pharmacokinetics and membrane technology have increased therapy sophistication.
- Limited robust evidence currently guides optimal extracorporeal therapy use in poisoning.
Purpose of the Study:
- To review scientific and technologic developments in extracorporeal therapies for poisoning.
- To summarize efforts to optimize the use of these therapies.
- To outline new research directions in the field.
Main Methods:
- Review of existing literature on extracorporeal therapies in poisoning.
- Formation of the Extracorporeal Treatments in Poisoning Workgroup (EXTRIP).
- Development of evidence-based guidelines for extracorporeal techniques.
Main Results:
- Extracorporeal therapy use in poisoning has a long history but lacks strong evidence.
- The EXTRIP initiative is creating guidelines based on available data.
- New techniques and membranes are emerging for enhanced treatment.
Conclusions:
- There is a critical need for evidence-based guidelines for extracorporeal therapy in poisoning.
- International collaboration (EXTRIP) is crucial for advancing treatment protocols.
- Ongoing research and technological innovation promise improved patient outcomes.
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