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Neurocognitive Function Following Therapy for Low-Grade Gliomas.
Mary Frances McAleer1, Paul D Brown1
1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Seminars in Radiation Oncology
|June 9, 2015
Summary
Low-grade gliomas (LGGs) in young patients require careful treatment monitoring. Therapies can impact long-term neurocognition and quality of life, necessitating a review of influencing factors.
Area of Science:
- Neuro-oncology
- Pediatric Neurology
- Clinical Psychology
Background:
- Low-grade gliomas (LGGs) are primary brain tumors common in children and young adults.
- LGGs typically present with a slow progression and good prognosis.
- Standard treatments include surgery, radiation, and chemotherapy, often in combination.
Purpose of the Study:
- To review factors affecting neurocognitive function in pediatric and young adult LGG patients.
- To analyze the impact of different treatment modalities on neurocognitive outcomes.
- To highlight the importance of long-term sequelae on quality of life.
Main Methods:
- Literature review of studies on low-grade gliomas.
- Analysis of baseline patient factors influencing neurocognition.
- Evaluation of treatment-related factors and their neurocognitive effects.
Main Results:
- Neurocognitive deficits can arise from both the tumor and its treatment.
- Specific treatment modalities have distinct effects on cognitive functions.
- Long-term survival in LGG patients underscores the need to manage treatment side effects.
Conclusions:
- Understanding the interplay of factors is crucial for optimizing neurocognitive outcomes in LGG survivors.
- Personalized treatment strategies may mitigate long-term neurocognitive impairment.
- Further research is needed to develop neuroprotective therapies for LGG patients.
