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Updated: Apr 11, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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Spatially and temporally controlled immune cell interactions using microscale tools.

Burak Dura¹, Joel Voldman¹

¹Research Laboratory of Electronics, Massachusetts Institute of Technology (MIT), 50 Vassar Street, Cambridge, MA 02139, USA; Electrical Engineering and Computer Science Department, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Microsystems Technology Laboratory, Massachusetts Institute of Technology (MIT), 60 Vassar Street, Cambridge, MA 02139, USA.

Current Opinion in Immunology

|June 9, 2015

Summary

New microscale tools offer unprecedented insights into complex immune cell interactions. These advanced technologies enable precise, high-throughput single-cell analysis, overcoming limitations of traditional methods for a deeper understanding of immunological responses.

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Area of Science:

Immunology
Biotechnology
Microfluidics

Background:

Cell-cell interactions are crucial for immune responses.
Traditional methods offer limited, fragmented views of these complex interactions.
There is a need for advanced tools to study immune cell communication.

Purpose of the Study:

To review recent advancements in microscale tools for studying immune cell interactions.
To highlight the potential of these tools in immunological research.
To discuss how microscale technologies overcome traditional method limitations.

Main Methods:

Review of emerging microscale tools and technologies.
Analysis of their capabilities in spatial and temporal control.
Discussion of multiplexed measurement and high-throughput single-cell analysis.

Main Results:

Microscale tools provide precise control over cell-cell interaction studies.
These tools enable high-throughput, single-cell analysis of immune responses.
Advancements facilitate more comprehensive and detailed investigations.

Conclusions:

Microscale tools are revolutionizing the study of immune cell interactions.
They offer enhanced capabilities beyond traditional experimental approaches.
These technologies promise to reveal new findings in immunology.