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Intratympanic injection in delayed endolymphatic hydrops.

Bo Liu1, Sulin Zhang, Yangming Leng

  • 1Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei Province , PR China.

Acta Oto-Laryngologica
|June 9, 2015
PubMed
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Intratympanic dexamethasone injection (ITD) shows promise for delayed endolymphatic hydrops (DEH). Intratympanic gentamicin injection (ITG) offers a simple vertigo control method for ipsilateral DEH.

Area of Science:

  • Otolaryngology
  • Neurology

Background:

  • Delayed endolymphatic hydrops (DEH) is a challenging inner ear disorder.
  • Current treatments for DEH vertigo can be invasive or have limited efficacy.

Purpose of the Study:

  • To evaluate the effectiveness of intratympanic dexamethasone injection (ITD) and intratympanic gentamicin injection (ITG) for treating DEH.
  • To compare the outcomes of ITD and ITG in managing vertigo symptoms associated with DEH.

Main Methods:

  • A cohort of 14 patients with DEH underwent audio-vestibular evaluation.
  • Ten patients received intratympanic injections: four with ITG for ipsilateral DEH, and six (five ipsilateral, one contralateral) with ITD.
  • Follow-up ranged from 8 to 48 months.

Main Results:

Keywords:
Endolymphatic hydropsdexamethasonegentamicininjectioninner ear

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  • ITG achieved complete or substantial vertigo control in 4 out of 9 ipsilateral DEH patients.
  • ITD provided complete or substantial vertigo control in 4 out of 6 patients (ipsilateral and contralateral DEH).
  • Significant reductions in vertigo intensity, frequency, duration, and improved functional levels were observed post-injection.

Conclusions:

  • Intratympanic dexamethasone injection (ITD) is a promising treatment for both contralateral and ipsilateral DEH.
  • Intratympanic gentamicin injection (ITG) serves as a straightforward chemical labyrinthectomy for controlling vertigo in ipsilateral DEH.