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Acanthosis nigricans: A fold (intertriginous) dermatosis
Zekayi Kutlubay1, Burhan Engin1, Orkhan Bairamov1
1Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey.
Acanthosis nigricans (AN) presents as hyperpigmented skin lesions, often indicating underlying insulin resistance or malignancy. This condition is increasingly observed in obese children and adolescents.
Area of Science:
- Dermatology
- Endocrinology
- Oncology
Background:
- Acanthosis nigricans (AN) is a mucocutaneous disorder.
- Characterized by hyperkeratotic, hyperpigmented skin lesions, typically symmetrical.
- Rarely affects oral mucosal surfaces.
Purpose of the Study:
- To summarize the clinical significance of Acanthosis nigricans.
- To highlight AN as a potential indicator of insulin resistance and malignancy.
- To review associated conditions including type 2 diabetes mellitus, obesity, and endocrinopathies.
Main Methods:
- Literature review of recent studies on Acanthosis nigricans.
- Analysis of AN's association with metabolic and oncologic conditions.
- Clinical observation of AN prevalence in pediatric populations.
Main Results:
- AN is increasingly prevalent in obese children and adolescents.
- AN serves as a cutaneous marker for insulin resistance.
- AN is associated with type 2 diabetes mellitus, obesity, endocrinopathies, drugs, and malignancies.
Conclusions:
- Acanthosis nigricans is a significant dermatological sign.
- Early recognition of AN is crucial for identifying associated systemic diseases.
- Further research is warranted to understand the pathophysiology and management of AN.
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