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Metabolic regulation in model ascomycetes--adjusting similar genomes to different lifestyles
Malcolm Whiteway1, Walters A Tebung1, Baharul I Choudhury1
1Biology Department, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada.
Abstract:
The related yeasts Saccharomyces cerevisiae and Candida albicans have similar genomes but very different lifestyles. These fungi have modified transcriptional and post-translational regulatory processes to adapt their similar genomes to the distinct biological requirements of the two yeasts. We review recent findings comparing the differences between these species, highlighting how they have achieved specialized metabolic capacities tailored to their lifestyles despite sharing similar genomes. Studying this transcriptional and post-transcriptional rewiring may improve our ability to interpret phenotype from genotype.
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