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Association between monoamine oxidase gene polymorphisms and smoking behavior: A meta-analysis
Xiaorong Yang1, Hui Chen1, Suyun Li1
1Department of Epidemiology and Biostatistics, Shandong University, Jinan 250012, Shandong, PR China.
Drug and Alcohol Dependence
|June 9, 2015
Summary
Monoamine oxidase gene (MAO) polymorphisms influence smoking behavior. Low activity MAO gene variants show a protective effect against heavy smoking and aid smoking cessation, particularly in males and Caucasians.
Area of Science:
- Genetics
- Behavioral Science
- Pharmacogenomics
Background:
- Inconsistent findings exist regarding the association between monoamine oxidase (MAO) gene polymorphisms and smoking behavior.
- This meta-analysis investigates specific MAO gene polymorphisms (MAO-A C1460T, MAO-A VNTR, MAO-B G644A) in relation to smoking habits.
Purpose of the Study:
- To systematically evaluate the association between MAO gene polymorphisms and smoking behavior.
- To clarify the conflicting results from previous individual studies.
Main Methods:
- A comprehensive literature search identified relevant studies.
- Meta-analysis was employed to calculate pooled effect sizes and confidence intervals.
- Heterogeneity was explored using meta-regression and sensitivity analyses; risk of bias was assessed via Egger's test.
Main Results:
- The T allele in MAO-A C1460T was associated with reduced heavy smoking risk (OR=0.66), especially in Caucasians.
- The active group in MAO-A VNTR was linked to increased failed smoking cessation in males (OR=1.49).
- The A allele in MAO-B G644A showed a reduced risk of heavy smoking in males (OR=0.20).
Conclusions:
- Low activity monoamine oxidase gene polymorphisms appear to confer a protective effect on smoking cessation and reduce smoking heaviness.
- Further research is needed to confirm these genetic associations and their clinical applications.
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