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Telmisartan.

Ahmed H H Bakheit1, Ahmed A Abd-Elgalil2, Bakheit Mustafa3

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|June 9, 2015
PubMed
Summary
This summary is machine-generated.

This study profiles telmisartan, an angiotensin-II receptor antagonist (ARB) for hypertension. It details the drug's properties, preparation, analysis, pharmacology, and stability, offering a comprehensive overview for researchers and clinicians.

Keywords:
DescriptionMethod of analysisPharmacokineticsPhysical characteristicsSpectral propertiesStabilitySynthesisTelmisartanUses

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Area of Science:

  • Pharmacology
  • Medicinal Chemistry
  • Analytical Chemistry

Background:

  • Telmisartan is a widely used angiotensin-II receptor antagonist (ARB) for managing hypertension.
  • ARBs function by blocking angiotensin-II type 1 receptors, reducing vascular smooth muscle contraction and lowering blood pressure.

Purpose of the Study:

  • To provide a comprehensive profile of telmisartan.
  • To outline its nomenclature, formulae, elemental analysis, and physical characteristics.
  • To detail its preparation, physicochemical properties, analytical methods, and pharmacological aspects.

Main Methods:

  • Physicochemical characterization including pKa, solubility, X-ray diffraction, and melting point.
  • Development and validation of stability-indicating analytical methods (HPLC, biodiffusion assay) under various stress conditions.
  • Comprehensive pharmacological evaluation, including actions, therapeutic uses, dosing, interactions, and adverse effects.

Main Results:

  • Detailed physicochemical and analytical data for telmisartan.
  • Validated methods for assessing drug stability under accelerated conditions (acidic, alkaline, oxidative, light, temperature, pH).
  • Extensive pharmacological information covering efficacy, safety, and drug interactions.

Conclusions:

  • The study presents a thorough profile of telmisartan, encompassing its chemical, physical, analytical, and pharmacological properties.
  • Validated stability-indicating methods are crucial for quality control and ensuring the efficacy of telmisartan formulations.
  • This comprehensive data serves as a valuable resource for understanding and utilizing telmisartan in clinical practice and further research.