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Evaluation of coat uniformity and taste-masking efficiency of irregular-shaped drug particles coated in a modified
Min Xu1, Paul Wan Sia Heng1, Celine Valeria Liew1
1a National University of Singapore, GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy , 18 Science Drive 4, 117543, Singapore, Singapore +65 6516 3870 ; +65 6779 1554 ; phalcv@nus.edu.sg.
Objective:
To explore the feasibility of coating irregular-shaped drug particles in a modified tangential spray fluidized bed processor (FS processor) and evaluate the coated particles for their coat uniformity and taste-masking efficiency.
Methods:
Paracetamol particles were coated to 20%, w/w weight gain using a taste-masking polymer insoluble in neutral and basic pH but soluble in acidic pH. In-process samples (5, 10 and 15%, w/w coat) and the resultant coated particles (20%, w/w coat) were collected to monitor the changes in their physicochemical attributes.
Results:
After coating to 20%, w/w coat weight gain, the usable yield was 81% with minimal agglomeration (< 5%). Some aerodynamic modifications to particle shape and surface morphology were observed for the in-process samples with 5 and 10% coat compared with the uncoated particles. A 15%, w/w coat was optimal for inhibiting drug release in salivary pH with subsequent fast dissolution in simulated gastric pH.
Conclusion:
The FS processor shows promise for direct coating of irregular-shaped drug particles with wide size distribution. The coated particles with 15% coat were sufficiently taste masked and could be useful for further application in orally disintegrating tablet platforms.
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