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Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
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Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
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Using the Race Model Inequality to Quantify Behavioral Multisensory Integration Effects
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Unpacking intoxication, racialising disability.

Mel Y Chen

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    |June 9, 2015
    PubMed
    Summary

    This study explores how concepts like toxicity and intoxication reveal shared logics across domains, impacting political justice and revealing racialized implications in finance and empire. It introduces

    Area of Science:

    • Interdisciplinary studies
    • Critical theory
    • Medical humanities

    Background:

    • Widespread use of medical concepts often extends beyond strict clinical applications.
    • Understanding shared logical frameworks across diverse domains is crucial for equitable engagement.

    Purpose of the Study:

    • To examine the complex interplay between 'toxicity' and 'intoxication'.
    • To assess the racialized conditions influencing these concepts in distinct geopolitical contexts.
    • To explore the political implications of shared conceptual logics.

    Main Methods:

    • Comparative analysis of 'toxicity' and 'intoxication' across different scenarios.
    • Examination of racial implications in financial and medical discourse.
    • Historical case studies from 19th-century British empire (US financial crisis, opium trade, disability studies).
    Keywords:
    Economics

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    Main Results:

    • Financial crisis discourse reveals racialized implications of 'non-toxic' finance capital and 'illiquid bodies'.
    • Opium's role in the 19th-century British empire highlights interanimations of race, disability, and temporality.
    • Conceptual metaphors of toxicity are not inherently more or less valid across different contexts.

    Conclusions:

    • Shared logics, often racialized, underpin concepts like toxicity and intoxication across medical, financial, and imperial domains.
    • An 'intoxicated method' is proposed, challenging idealized research positions by critically disabling analytical lenses.
    • This approach fosters a more politically just engagement with complex societal issues.