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Super-secondary structure peptidomimetics: design and synthesis of an α-α hairpin analogue
Laura Nevola1, Johanna M Rodriguez1, Sam Thompson2
1Yale University, Department of Chemistry, P.O. Box 208107, New Haven, CT 06511.
Abstract:
The α-α helix motif presents key recognition domains in protein-protein and protein-oligonucleotide binding, and is one of the most common super-secondary structures. Herein we describe the design, synthesis and structural characterization of an α-α hairpin analogue based on a tetra-coordinated Pd(II) bis-(iminoisoquinoline) complex as a template for the display of two α-helix mimics. This approach is exemplified by the attachment of two biphenyl peptidomimetics to reproduce the side-chains of the i and i+4 residues of two helices.
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