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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

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Nephrotic syndrome and Hodgkin lymphoma in children. Report of two cases

A Pourtsidis¹, D Doganis¹, M Baka¹

¹Oncology Department of "P & A. Kyriakou" Children's Hospital, Athens, Greece.

|June 9, 2015

Abstract

Background:

The association of nephrotic syndrome (NS) and Hodgkin's lymphoma (HL), although rare, is well recognised. In the majority of cases of HL, minimal change NS is detected.

Description Of Cases:

This report presents the occurrence of NS in two children with HL. In the first case, NS preceded the diagnosis of lymphoma by 3 months, while in the other child, the two disorders occurred simultaneously. In both cases, clinical manifestations and laboratory parameters (proteinuria) of NS resolved after effective treatment for active HL.

Conclusion:

Prolonged proteinuria may be a paraneoplastic syndrome and HL should be considered in the diagnosis as it is crucial for the management of both entities.

Keywords:

Hodgkin children lymphoma nephrotic syndrome paraneoplastic

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