Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simple and versatile fluorescence-based method to enhance prime editing in human pluripotent stem cells.

BMC methods·2026
Same author

Comprehensive and low-cost machine learning models for predicting MASLD prevalence: cross-sectional evidence from the amol cohort study (AmolCS).

Journal of health, population, and nutrition·2026
Same author

Restoring anisotropy after myocardial injury: strategies to align transplanted human induced pluripotent stem-cell-derived cardiomyocytes.

Experimental & molecular medicine·2026
Same author

An integrative transcriptomic analysis for prognosis and tumor microenvironment in HBV/HCV-associated hepatocellular carcinoma.

Molecular therapy. Oncology·2026
Same author

Double-layer microencapsulation of <i>Lacticaseibacillus rhamnosus</i> using sodium alginate and nano-mucilages of Qodume Shirazi and Camelina sativa for probiotic goat milk dessert.

Biotechnology reports (Amsterdam, Netherlands)·2026
Same author

Multimodal profiling of CAR T cells against glioblastoma using a microengineered 3D tumor-on-a-chip model.

Bioactive materials·2026

Related Experiment Video

Updated: Apr 11, 2026

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

8.2K

Biomaterial Approaches for Stem Cell-Based Myocardial Tissue Engineering.

Josh Cutts1, Mehdi Nikkhah1, David A Brafman1

  • 1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.

Biomarker Insights
|June 9, 2015
PubMed
Summary

Biomaterials enhance stem cell use for heart repair by improving differentiation and delivery. This approach aids in regenerating damaged cardiac tissue with functional cells and vascularized constructs.

Keywords:
biomaterialscardiac regenerationpluripotent stem cellstem cell

More Related Videos

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Published on: March 19, 2013

11.7K
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.7K

Related Experiment Videos

Last Updated: Apr 11, 2026

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

8.2K
Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Published on: March 19, 2013

11.7K
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.7K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Biology

Background:

  • Adult and pluripotent stem cells offer potential for cardiac tissue repair.
  • Current limitations include inefficient in vitro differentiation and poor in vivo delivery of stem cells.
  • Effective cardiac regeneration requires overcoming these challenges.

Purpose of the Study:

  • To review biomaterial-based strategies for directing stem cell fate in cardiac regenerative therapies.
  • To explore methods for enhancing in vitro differentiation and in vivo integration of stem cells.
  • To highlight emerging trends in biomaterial-assisted cardiac repair.

Main Methods:

  • Engineering of natural and synthetic biomaterials to guide stem cell differentiation.
  • Utilizing biomaterials for improved stem cell delivery and integration in damaged myocardium.
  • Investigating biomaterial applications for delivering pro-survival factors and vascularized tissue.

Main Results:

  • Biomaterials can effectively direct stem cell differentiation towards cardiac lineages in vitro.
  • Engineered biomaterials improve the survival, integration, and differentiation of transplanted stem cells in vivo.
  • Emerging strategies focus on creating functional, vascularized cardiac tissue using stem cell-biomaterial constructs.

Conclusions:

  • Biomaterial-based approaches are crucial for advancing stem cell therapies in cardiac regeneration.
  • These strategies address key limitations in stem cell differentiation and delivery for heart repair.
  • Future directions involve sophisticated biomaterial designs for enhanced functional tissue regeneration.