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Updated: Apr 11, 2026
09:08
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
17.9K
Bioinspired iterative synthesis of polyketides.
Kuan Zheng1, Changmin Xie1, Ran Hong1
1CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Shanghai, China.
Frontiers in Chemistry
|June 9, 2015
Summary
Nature
Area of Science:
- Organic Chemistry
- Biochemistry
- Synthetic Chemistry
Background:
- Nature utilizes enzymatic iterative assembly for biopolymer and natural product synthesis.
- This modular strategy inspires efficient molecular synthesis in chemistry.
- Polyketide natural products are a diverse and biologically significant class of molecules.
Purpose of the Study:
- To provide an overview of iterative strategies in synthetic chemistry.
- To emphasize the total synthesis of polyol-embedded polyketides.
- To discuss the limitations of current iterative module strategies.
Main Methods:
- Review of iterative assembly strategies in supramolecular chemistry.
- Focus on the application of these strategies in natural product synthesis.
- Analysis of diastereoselectivity and enantioselectivity in known modules.
Main Results:
- Iterative strategies offer modularity and efficiency in synthesizing complex molecules.
- Total synthesis of polyol-embedded polyketides showcases the power of this approach.
- Current modules have limitations in controlling stereoselectivity.
Conclusions:
- Iterative assembly is a powerful strategy for synthesizing complex natural products.
- Further development is needed to overcome stereoselectivity challenges.
- Anticipation of more efficient and practical iterative strategies in the future.
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