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Related Experiment Video

Updated: Apr 11, 2026

Preparation and Characterization of SDF-1&#945;-Chitosan-Dextran Sulfate Nanoparticles
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Chitosan nanoparticles as adenosine carriers.

Mehdi Kazemzadeh-Narbat1, Marla Reid, Marianne Su-Ling Brooks

  • 1Department of Process Engineering and Applied Science, Dalhousie University , Halifax , Canada .

Journal of Microencapsulation
|June 9, 2015
PubMed
Summary

Chitosan nanoparticles effectively delivered adenosine, an essential heart rhythm drug, overcoming its short in vivo half-life. This research demonstrates a promising nanocarrier for improved adenosine therapy.

Keywords:
Adenosinechitosandrug delivery systemsnanoparticles

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacology

Background:

  • Adenosine is crucial for treating cardiac arrhythmias but has a very short in vivo half-life (<10 seconds).
  • Effective clinical delivery of adenosine is hindered by its rapid degradation.
  • Chitosan nanoparticles (CS NPs) offer potential as a drug delivery vehicle.

Purpose of the Study:

  • To evaluate chitosan nanoparticles (CS NPs) as a drug delivery system for adenosine.
  • To assess the encapsulation efficiency and loading capacity of adenosine within CS NPs.
  • To characterize the physical properties and in vitro release profile of adenosine-loaded CS NPs.

Main Methods:

  • Adenosine was encapsulated into chitosan nanoparticles using ionic gelation.
  • Nanoparticle size, shape, encapsulation efficiency, and loading capacity were determined.
  • In vitro release studies were conducted using spectrophotometry.

Main Results:

  • Chitosan nanoparticles successfully encapsulated adenosine with 20% encapsulation efficiency and 3% loading capacity.
  • The CS NPs exhibited a spherical shape with an average size of 260.6 ± 20.1 nm.
  • In vitro release studies showed an initial burst release, followed by a plateau and sustained release over one week.

Conclusions:

  • Chitosan nanoparticles provide a viable system for delivering adenosine.
  • The developed CS NPs demonstrate potential for improving adenosine's therapeutic efficacy by extending its release profile.
  • This nanodelivery approach could overcome the limitations of adenosine's short half-life in clinical settings.