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Updated: Apr 11, 2026
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Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
Published on: March 28, 2012
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Functional subregions of the human entorhinal cortex
Anne Maass1, David Berron1, Laura A Libby2
1Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Elife
|June 9, 2015
Summary
This study reveals functional divisions within the human entorhinal cortex (EC) using high-resolution fMRI. These divisions mirror anatomical connections, linking specific EC subregions to the perirhinal cortex (PRC) and parahippocampal cortex (PHC).
Area of Science:
- Neuroscience
- Cognitive Neuroscience
Background:
- The entorhinal cortex (EC) is crucial for neocortical-hippocampal interactions.
- Rodent and primate studies suggest EC subregions connect differentially with perirhinal cortex (PRC), parahippocampal cortex (PHC), and hippocampal subfields.
Purpose of the Study:
- To identify functional subdivisions within the human EC using high-resolution 7 Tesla functional magnetic resonance imaging (fMRI).
- To investigate if these functional subdivisions correlate with known anatomical connectivity patterns.
Main Methods:
- High-resolution fMRI at 7 Tesla was employed on two independent human datasets.
- Intrinsic functional connectivity was analyzed to map EC subdivisions.
Main Results:
- Anterior-lateral EC showed preferential connectivity with the PRC.
- Posterior-medial EC demonstrated preferential connectivity with the PHC.
- These EC subregions exhibited differential connectivity with the subiculum along proximal-distal and anterior-posterior axes.
Conclusions:
- The human EC can be functionally divided into subregions.
- These functional divisions align with established anatomical connectivity in rodents and nonhuman primates.
- This provides evidence for conserved connectivity patterns across species.
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