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Sonographic assessment of abdominal fat distribution during the first year of infancy
Christina Brei1, Daniela Much1, Ellen Heimberg2
1Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Insights
Ultrasonography (US) is a reliable method to measure infant abdominal fat. Subcutaneous fat increased then decreased, while preperitoneal fat continuously grew during the first year.
Area of Science:
- Pediatric Endocrinology
- Developmental Biology
- Medical Imaging
Background:
- Limited longitudinal data exists on infant fat distribution in early life.
- Understanding early adipose tissue development is crucial for long-term health outcomes.
Purpose of the Study:
- To investigate the development of abdominal subcutaneous (SC) and preperitoneal (PP) fat depots in infants up to one year of age.
- To assess the feasibility and reproducibility of ultrasonography (US) for quantifying these fat depots.
- To compare US findings with skinfold thickness (SFT) and anthropometric measurements.
Main Methods:
- Longitudinal study involving 162 healthy infants up to 1 year postpartum.
- Noninvasive ultrasonography (US) used to measure SC and PP fat thickness.
- Comparison of US data with skinfold thickness (SFT) and anthropometry at 6 weeks, 4 months, and 1 year.
Main Results:
- Ultrasonography (US) demonstrated reproducibility for quantifying abdominal SC and PP adipose tissue (AT) in infants.
- SC fat thickness increased from 6 weeks to 4 months, then decreased at 1 year; PP fat thickness continuously increased.
- Girls exhibited higher SC fat mass than boys, with no sex difference in PP fat.
- SC fat correlated strongly with SFT, while PP fat showed weak correlation with anthropometric measures.
Conclusions:
- Ultrasonography (US) is a feasible and reproducible method for quantifying abdominal fat mass in infants up to one year of age.
- Abdominal SC and PP fat depots exhibit distinct developmental patterns during the first year of life.
Background:
Longitudinal data regarding the fat distribution in the early postnatal period is sparse.
Methods:
We performed ultrasonography (US) as a noninvasive approach to investigate the development of abdominal subcutaneous (SC) and preperitoneal (PP) fat depots in infants ≤1 y and compared longitudinal US data with skinfold thickness (SFT) measurements and anthropometry in 162 healthy children at 6 wk, 4 mo, and 1 y postpartum.
Results:
US was found to be a reproducible method for the quantification of abdominal SC and PP adipose tissue (AT) in this age group. Thickness of SC fat layers significantly increased from 6 wk to 4 mo and decreased at 1 y postpartum, whereas PP fat layers continuously increased. Girls had a significantly higher SC fat mass compared to boys, while there was no sex-specific difference in PP fat thickness. SC fat layer was strongly correlated with SFT measurements, while PP fat tissue was only weakly correlated with anthropometric measures.
Conclusion:
US is a feasible and reproducible method for the quantification of abdominal fat mass in infants ≤1 y of age. PP and SC fat depots develop differentially during the first year of life.
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