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Image-guided surgery using multimodality strategy and molecular probes
Lei Xi1, Hubei Jiang1,2
1School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, China.
Abstract:
The ultimate goal of cancer surgery is to maximize the excision of tumorous tissue with minimal damage to the collateral normal tissues, reduce the postoperative recurrence, and improve the survival rate of patients. In order to locate tumor lesions, highlight tumor margins, visualize residual disease in the surgical wound, and map potential lymph node metastasis, various imaging techniques and molecular probes have been investigated to assist surgeons to perform more complete tumor resection. Combining imaging techniques with molecular probes is particularly promising as a new approach for image-guided surgery. Considering inherent limitations of different imaging techniques and insufficient sensitivity of nonspecific molecular probes, image-guided surgery with multimodality strategy and specific molecular probes appears to be an optimal choice. In this article, we briefly describe typical imaging techniques and molecular probes followed by a focused review on the current progress of multimodal image-guided surgery with specific molecular navigation. We also discuss optimal strategy that covers all stages of image-guided surgery including preoperative scanning of tumors, intraoperative inspection of surgical bed and postoperative care of patients.
Insights
Image-guided surgery uses advanced imaging and molecular probes to improve cancer resection. A multimodal strategy with specific probes offers an optimal approach for better patient outcomes.
Area of Science:
- Oncology
- Surgical Innovation
- Medical Imaging
Background:
- Maximizing tumor excision while preserving healthy tissue is crucial for cancer surgery.
- Current methods struggle with precise tumor margin identification and detecting residual disease.
- Advanced imaging and molecular probes are being explored to enhance surgical precision.
Purpose of the Study:
- To review current imaging techniques and molecular probes for image-guided surgery.
- To highlight progress in multimodal image-guided surgery using specific molecular navigation.
- To discuss optimal strategies for image-guided surgery across all patient care stages.
Main Methods:
- Review of typical imaging techniques and molecular probes.
- Focused review of multimodal image-guided surgery advancements.
- Discussion of preoperative, intraoperative, and postoperative strategies.
Main Results:
- Combining imaging techniques with molecular probes shows promise for image-guided surgery.
- Multimodality strategies and specific molecular probes address limitations of individual techniques.
- Optimal strategies encompass preoperative scanning, intraoperative inspection, and postoperative care.
Conclusions:
- Multimodal image-guided surgery with specific molecular probes represents an optimal approach.
- This strategy aims to improve tumor resection completeness and patient survival rates.
- Comprehensive planning from preoperative to postoperative care is essential for successful image-guided surgery.
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