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Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
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A standardized mean difference effect size for multiple baseline designs across individuals.

Larry V Hedges1, James E Pustejovsky1, William R Shadish2

  • 1Statistics, Northwestern University, Chicago, USA.

Research Synthesis Methods
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PubMed
Summary
This summary is machine-generated.

This study introduces a new effect size measure for multiple baseline single-case designs, enabling direct comparison with between-subjects studies. This advances treatment effect evaluation in behavioral and clinical research.

Keywords:
effect sizehierarchical linear modelmultiple baseline designssingle-case design

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Area of Science:

  • Psychology
  • Behavior Analysis
  • Medicine

Background:

  • Single-case designs evaluate treatment effects through repeated outcome measures within individuals.
  • Existing research focuses on summarizing findings and developing comparable effect size indices.
  • Previous work defined effect sizes for treatment reversal (AB)(k) designs.

Purpose of the Study:

  • To extend effect size estimation to multiple baseline single-case designs.
  • To propose methods for estimating effect size and its variance.
  • To demonstrate the applicability of the proposed methods.

Main Methods:

  • Proposed novel estimation methods for effect size and variance in multiple baseline designs.
  • Conducted simulation studies to evaluate the proposed estimators.
  • Applied the methods to two real-world case study applications.

Main Results:

  • The proposed estimation methods provide a comparable effect size measure for multiple baseline designs.
  • Simulation studies support the validity and utility of the estimators.
  • Applications demonstrate the practical use of the effect size measure.

Conclusions:

  • The developed effect size measure facilitates standardized comparison of findings across single-case and between-subjects studies.
  • This contributes to more robust meta-analysis and evidence synthesis in fields utilizing single-case designs.
  • The approach enhances the interpretability and comparability of treatment effect evaluations.