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Related Experiment Videos

Mongolian spots associated with cleft lip.

S Kurata1, Y Ohara, S Itami

  • 1Department of Dermatology, Medical College of Oita, Japan.

British Journal of Plastic Surgery
|November 1, 1989
PubMed
Summary
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Dermal melanocytosis, a common finding in Asian infants, occurs frequently in newborns with cleft lip, even without visible skin spots. This condition involves pigment cells in the skin, similar to Mongolian spots.

Area of Science:

  • Dermatology
  • Pediatrics
  • Genetics

Background:

  • Cleft lip is a common congenital condition.
  • Pigmented macules can be present in newborns.
  • Dermal melanocytosis is a known condition, often seen as Mongolian spots.

Purpose of the Study:

  • To investigate the incidence of dermal melanocytosis in newborns with cleft lip.
  • To determine if pigmented macules correlate with histological findings of dermal melanocytosis.
  • To compare the incidence in cleft lip infants to that of Mongolian spots.

Main Methods:

  • Clinical examination of 66 newborns with cleft lip for pigmented macules.
  • Histological examination using serial sections on 47 cases.
  • Dopa reaction and anti-melanocyte antibody staining for fusiform cells.

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Main Results:

  • 13% of newborns with cleft lip had visible pigmented macules.
  • 85% of examined cases showed histological evidence of dermal melanocytosis.
  • Dermal melanocytosis was present in 70% of cases without visible macules.

Conclusions:

  • Dermal melanocytosis is highly prevalent in newborns with cleft lip, often subclinical.
  • The findings suggest a potential link between cleft lip and dermal melanocytosis.
  • The incidence is comparable to that of Mongolian spots in Asian infants.