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Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development

Meina Liang1, Martin Schwickart1, Amy K Schneider1

  • 1Department of Clinical Pharmacology and DMPK, Medimmune, LLC, Mountain View, California, 94043.

Cytometry. Part B, Clinical Cytometry
|June 9, 2015
PubMed

Keywords:
PKPD relationshipanimal and human studiesbiopharmaceuticalclinical trialdose selectiondrug developmentflow cytometrypharmacodynamic biomarkerreceptor occupancytarget binding

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