Related Experiment Video
Updated: Apr 11, 2026
10:08
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
Published on: May 18, 2022
4.4K
Early life events can shape aging and longevity.
1Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, Illinois, USA. abartke@siumed.es.
Current Aging Science
|June 10, 2015
Summary
Nutritional and hormonal factors during early life significantly impact lifespan. Calorie restriction in young mice and growth hormone in dwarf mice demonstrate how developmental signals influence longevity and aging trajectories.
Area of Science:
- Developmental biology
- Endocrinology
- Gerontology
Background:
- Nutritional and hormonal signals during development are increasingly recognized for their influence on longevity.
- Studies in mice suggest a link between early-life conditions and lifespan.
- Hormonal status during development can affect aging processes.
Purpose of the Study:
- To investigate the impact of developmental nutritional and hormonal signals on longevity.
- To understand how early-life interventions influence aging trajectories.
Main Methods:
- Examining the effects of preweaning calorie restriction on mouse lifespan.
- Investigating the impact of growth hormone replacement therapy on hypopituitary dwarf mouse longevity during development.
Main Results:
- Mild calorie restriction during the preweaning period in mice led to increased longevity compared to controls.
- Growth hormone replacement therapy in long-lived hypopituitary dwarf mice reduced their lifespan when administered during the pre- and peri-pubertal period.
Conclusions:
- The availability of nutrients and levels of anabolic hormones during development critically influence the trajectory of aging.
- Early-life developmental signals play a crucial role in determining lifespan and aging processes.
More Related Videos
08:53Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
Published on: January 26, 2024
1.8K
10:39A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
6.9K
Related Concept Videos
01:26Aging
1.0K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.0K
01:19The Effect of Aging on Tissues
4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K
01:20Lifestyle Factors and Health
636
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
636
01:37Mitochondria
21.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.5K
02:20Longitudinal Research
13.7K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.7K
01:30Development of Human Microbiota
41
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
41