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Mood changes after right-hemisphere lesions.

S E Starkstein1, R G Robinson, M A Honig

  • 1Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.

The British Journal of Psychiatry : the Journal of Mental Science
|July 1, 1989
PubMed
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Right-hemisphere stroke patients experienced mood changes like depression or cheerfulness. Major depression was linked to parietal cortex lesions and psychiatric history, suggesting different mechanisms than left-hemisphere strokes.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurology

Background:

  • Stroke can lead to emotional and behavioral changes.
  • The specific impact of right-hemisphere strokes on mood requires further investigation.
  • Understanding lesion location and mood alterations is crucial for patient care.

Purpose of the Study:

  • To investigate the prevalence and characteristics of mood changes in acute stroke patients with right-hemisphere lesions.
  • To identify specific lesion locations associated with different mood alterations.
  • To compare the etiology of depression following right-hemisphere versus left-hemisphere lesions.

Main Methods:

  • Ninety-three patients with acute right-hemisphere stroke lesions were assessed for mood changes.
  • Patients were categorized into groups: no mood change, undue cheerfulness, major depression, and minor depression.

Related Experiment Videos

  • Demographic variables, neurological deficits, activities of daily living, cognitive impairment, social support, familial psychiatric history, and lesion locations were analyzed.

    • Main Results:

    • Major depression was associated with a higher frequency of familial psychiatric history and parietal cortex lesions.
    • Undue cheerfulness was significantly linked to lesions in the right frontal operculum.
    • No significant differences were found in other demographic, neurological, or functional variables between groups.

    Conclusions:

    • Major depression following right-hemisphere lesions may differ in etiology and mechanism from depression following left-hemisphere lesions.
    • Specific brain regions in the right hemisphere, such as the parietal cortex and frontal operculum, are implicated in distinct mood disturbances post-stroke.
    • These findings highlight the lateralized effects of stroke on emotional regulation.