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[Neonatal effects of propofol administered to the mother in anesthesia in cesarean section]

P Dailland1, P Jacquinot, J D Lirzin

  • 1Département d'Anesthésie et de Réanimation, Groupe Hospitalier Cochin-Maternités, Paris.

Cahiers D'Anesthesiologie
|October 1, 1989
PubMed

Propofol, 2-6 diisopropylphenol ("Diprivan", ICI) has been shown to be safe and effective for induction and maintenance of anesthesia when injected intravenously. Its pharmacological profile suggests that it may prove to be a useful agent in obstetric anesthetic practice. But, obstetrics is a specialized field in which the acute effects of the anesthetic agent on the fetus must be considered. This open non comparative study was therefore designed to investigate the neonatal assessments when propofol was used either for induction of anesthesia or for induction and maintenance of anesthesia during elective cesarean section. This study was conducted in two separate phases according to the use of propofol. In both phases, anesthesia was induced with an intravenous bolus of 2.5 mg.kg-1 of propofol. In phase 1 (n = 10), anesthesia was maintained with 50% nitrous oxide in oxygen and halothane. In phase 2 (n = 11), a continuous infusion of propofol at a rate of 5 mg.kg-1.h-1 was started after the induction dose. At time of delivery, blood samples were taken from maternal artery, umbilical vein and artery for acid-base and blood gas status. The condition of the infant was evaluated using Apgar score at 1, 5 and 10 min, time to sustained spontaneous respiration and the Neurologic and Adaptative Capacity Score was assessed at 30 min, 2 hours and 24 hours after birth. Maternal and neonatal blood gas tensions and acid-base status at delivery were within the normal clinical limits in both phases and compared favorably with results published by others workers using established methods of anesthesia.(ABSTRACT TRUNCATED AT 250 WORDS)

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