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Published on: December 3, 2020
Introduction: Metals in Biology: METALS AT THE HOST-PATHOGEN INTERFACE
1From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 f.guengerich@vanderbilt.edu.
Abstract:
This seventh Metals in Biology Thematic Series deals with the metal-based interactions of mammalian hosts with pathogens. Both pathogens and hosts have complex regulatory systems for metal homeostasis. Understanding these provides strategies for fighting pathogens, either by excluding essential metals from the microbes, by delivery of excess metals to cause toxicity, or by complexing metals in microorganisms. Intervention is possible by delivery of complexing reagents or by targeting the microbial regulatory apparatus.
Insights
This study explores how metals influence interactions between mammalian hosts and pathogens. Understanding metal regulation in both offers strategies to combat infections by controlling metal availability.
Area of Science:
- Metallomics
- Host-Pathogen Interactions
- Microbial Pathogenesis
Background:
- Mammalian hosts and pathogens possess intricate metal homeostasis regulatory systems.
- Metal ions play crucial roles in the biological processes of both hosts and microbes.
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